| Company | State | Location | Workers | Notice date |
| United States Enrichment | KY | McCracken | 450 | 2000-02-07 |
| Outboard Marine | IL | Waukegan, 90 Sea Hourse Drive | 385 | 2000-02-07 |
| Tyco Electronics | KY | Crittenden | 305 | 2000-02-21 |
| Quebecor World Aurora | IL | AURORA, 780 MCCLURE ROAD | 300 | 2000-02-15 |
| Douglas Community Medical Center | OR | ROSEBURG | 259 | 2000-02-28 |
| Genicom | KY | Jefferson | 259 | 2000-02-21 |
| ST Paul Federal Bank | IL | MT PROSPECT, 1501 FEEHANVILLE ROAD | 250 | 2000-02-23 |
| Russell Corporation, Geneva | AL | Geneva | 207 | 2000-02-04 |
| Halstead Hospital | KS | — | 181 | 2000-02-14 |
| Glenn Enterprises | AL | Sulligent | 163 | 2000-02-04 |
| Ruby Tuesday | AL | Mobile | 160 | 2000-02-11 |
| Ameriserve Food Distribution | IL | GRIDLEY, 202 NORTH FORD STREET | 147 | 2000-02-04 |
| Qwik Tool & Manufacturing | KY | Fayette | 130 | 2000-02-07 |
| Clarion Manufacturing | KY | Boone | 108 | 2000-02-01 |
| Kleinert's Inc. of Alabama | AL | Elba | 100 | 2000-02-22 |