| Company | State | Location | Workers | Notice date |
| Crothall Healthcare | KY | Jefferson | 350 | 2000-04-21 |
| Personal Products | IL | WILMINGTON, 901 EAST KANKAKEE RIVER DRIVE | 249 | 2000-04-19 |
| Celestica | KY | Wolfe | 218 | 2000-04-07 |
| JC Penney Store No 145 | IL | CHAMPAIGN, MARKET PLACE MALL 1000 NORTH NEIL STREET | 185 | 2000-04-10 |
| Landstar | KY | Hopkins | 178 | 2000-04-03 |
| Willamette Ind/Dallas Plywood | OR | DALLAS | 174 | 2000-04-19 |
| Green River Steel | KY | Daviess | 169 | 2000-04-07 |
| Metropolitan Public Defender | OR | PORTLAND | 147 | 2000-04-27 |
| Ramada Harvey Hotel | IL | HARVEY, 17040 SOUTH HALSTED STREET | 122 | 2000-04-17 |
| Knowles Electronics | IL | ELGIN, 440 S MCLEAN BLVD | 121 | 2000-04-12 |
| Comdata | AL | Birmingham | 120 | 2000-04-27 |
| Parsons Telecom | KY | Statewide | 112 | 2000-04-03 |
| Midwest Internet | IL | CARBONDALE, 300 EAST MAIN STREET | 109 | 2000-04-18 |
| Consolidation Coal/Rend Lake Mine | IL | SESSER, ROUTE 148 NORTH, BOX 566 | 106 | 2000-04-15 |
| Knowles Electronics | IL | ITASCA, 1151 MAPLEWOOD DRIVE | 94 | 2000-04-12 |