| Company | State | Location | Workers | Notice date |
| Santander Consumer | CO | Arapahoe/Douglas | 417 | 2021-03-23 |
| Novartis Gene Therapies | CO | Boulder | 400 | 2021-03-24 |
| Medline Industries | CA | Temecula, Riverside County | 360 | 2021-03-23 |
| Curative | CA | San Dimas, Los Angeles County | 180 | 2021-03-23 |
| Fresno Economic Opportunities Commission - Head Start 0-5 Program | CA | Fresno, Fresno County | 112 | 2021-03-23 |
| Epic Ventures | CA | Santa Rosa, Sonoma County | 98 | 2021-03-23 |
| Ovintive | TX | Karnes City, Karnes | 95 | 2021-03-25 |
| Independent Management Business Center | FL | TAMPA, FL, 33614 | 94 | 2021-03-22 |
| Liquid Controls | IL | Lake Bluff, 105 Albrecht Dr | 87 | 2021-03-26 |
| Orlando Airport Marriott Lakeside | FL | ORLANDO, FL, 32822 | 69 | 2021-03-23 |
| General Monitors | CA | Lake Forest, Orange County | 63 | 2021-03-25 |
| Dairyland Power Cooperative | WI | Genoa | 63 | 2021-03-25 |
| CSG Systems | TX | Austin, Travis | 57 | 2021-03-23 |
| GenOn Energy Services | MD | 25100 Chalk Point Road Aquasco, MD 20608 | 57 | 2021-03-24 |
| Blizzard Entertainment | CA | Irvine, Orange County | 55 | 2021-03-23 |