| Company | State | Location | Workers | Notice date |
| Houweling Nurseries Oxnard | CA | Camarillo, Ventura County | 486 | 2021-06-22 |
| Forfeiture Support Associates | CA | Laguna Niguel, Orange County | 440 | 2021-06-10 |
| Hyatt Regency McCormick | IL | Chicago, 2233 South Martin Luther King Drive | 384 | 2021-06-28 |
| Molded Fiber Glass | SD | Aberdeen | 300 | 2021-06-07 |
| Katerra Tracy Facility | CA | Tracy, San Joaquin County | 287 | 2021-06-10 |
| Clearwater Paper | WI | Neenah | 285 | 2021-06-02 |
| Chicago Athletic Association | IL | Chicago, 12 South Michigan Avenue | 276 | 2021-06-04 |
| Adient | IL | Sycamore, 1701 Bethany Rd | 262 | 2021-06-10 |
| Hot Topic | CA | City of Industry, Los Angeles County | 261 | 2021-06-15 |
| Katerra | AZ | Scottsdale | 251 | 2021-06-01 |
| First Student | CA | San Francisco, San Francisco County | 228 | 2021-06-03 |
| Sodexo, Inc. and Affiliates | FL | MELBOURNE, FL, 32901 | 212 | 2021-06-30 |
| Staples Contract & Commercial | NJ | Secaucus | 194 | 2021-06-01 |
| CORE Community Organized Relief Effort | CA | Los Angeles, Los Angeles County | 192 | 2021-06-01 |
| First Student | CA | San Francisco, San Francisco County | 188 | 2021-06-10 |