| Company | State | Location | Workers | Notice date |
| United Airlines - SFO | CA | San Francisco, San Francisco County | 3,139 | 2021-02-23 |
| United Airlines - LAX | CA | Los Angeles, Los Angeles County | 662 | 2021-02-23 |
| Amgen | CA | Thousand Oaks, Ventura County | 531 | 2021-02-23 |
| Waddell & Reed | KS | Mission, 6300 Lamar Avenue; Mission, Kansas 66202 | 434 | 2021-02-26 |
| Panasonic Avionics | CA | Lake Forest, Orange County | 425 | 2021-02-23 |
| Flying Food Group | CA | South San Francisco, San Mateo County | 226 | 2021-02-25 |
| Sensata Technologies | CA | Carpinteria, Santa Barbara County | 207 | 2021-02-25 |
| Marriott Hotel Services | CA | Palm Desert, Riverside County | 203 | 2021-02-25 |
| Punch Bowl Chicago West Loop | IL | Chicago, 310 N. Green Street | 198 | 2021-02-26 |
| Gilead Sciences | CA | Foster City, San Mateo County | 179 | 2021-02-24 |
| Marriott Hutchinson Island Beach Resort, Golf & Marina | FL | STUART, FL, 34996 | 169 | 2021-02-25 |
| Rapid Displays | CA | Union City, Alameda County | 165 | 2021-02-25 |
| Johnson & Johnson Consumer | CA | Los Angeles, Los Angeles County | 155 | 2021-02-26 |
| Wisconsin Physicians Services Insurance | WI | Rothschild, Monona | 128 | 2021-02-26 |
| Vistana California Management | CA | Palm Desert, Riverside County | 123 | 2021-02-24 |