| Company | State | Location | Workers | Notice date |
| Watsonville Community Hospital | CA | Santa Cruz County | 677 | 2021-11-30 |
| Watsonville Community Hospital | CA | Santa Cruz County | 658 | 2021-11-30 |
| Interfirst Mortgage | IL | Rosemont, 9525 W. Bryn Mawr Ave., Suite 400 | 544 | 2021-11-18 |
| National Education Partners | AZ | Scottsdale | 423 | 2021-11-04 |
| MV Transportation | CA | Orange County | 333 | 2021-11-08 |
| MWN Community Hospital | CA | Los Angeles County | 328 | 2021-11-10 |
| Glen Ivy Hot Springs | CA | Riverside County | 262 | 2021-11-15 |
| Coverance Insurance Solutions | CA | Los Angeles County | 258 | 2021-11-10 |
| Terre du Soleil | CA | Napa County | 200 | 2021-11-10 |
| Eckerd Community Alternatives - Circuit 6 | FL | LARGO, FL, 33771 | 197 | 2021-11-09 |
| Baptist Health Care | FL | PENSACOLA, FL, 32501 | 188 | 2021-11-30 |
| University Center Club at Florida State University | FL | TALLAHASSEE, FL, 32306 | 188 | 2021-11-04 |
| Franklin Templeton | CA | Sacramento County | 185 | 2021-11-24 |
| Franklin Templeton | FL | SAINT PETERSBURG, FL, 33716 | 175 | 2021-11-29 |
| Laredo Transit Management-El Metro Transit | TX | Laredo, Webb | 168 | 2021-11-30 |