| Company | State | Location | Workers | Notice date |
| Miller's Health Systems | IN | Indianapolis, Wakarusa, Tipton, Sullivan, Rushville, Peru, LaGrange, and Huntington | 691 | 2022-05-02 |
| Watsonville Community Hospital (Update) | CO | Rural Consortium (Salida) | 658 | 2022-05-11 |
| Armstrong Flooring | IL | Kankakee, 1401 N Hobbie Ave | 337 | 2022-05-24 |
| Preferred Meal Systems | IL | Berkeley, 5240 Saint Charles Rd | 307 | 2022-05-19 |
| NDSM Chemung | IL | Harvard, 6303 Maxon Rd | 247 | 2022-05-10 |
| Akorn Operating | NJ | Somerset | 240 | 2022-05-01 |
| FIS | AL | Birmingham | 214 | 2022-05-03 |
| Toyota Motor Credit | MD | 500 Red Brook Boulevard Owings Mills, MD 21117 | 196 | 2022-05-02 |
| Aramark at Georg Washington University | DC | Washington, DC | 192 | 2022-05-31 |
| First Student | AK | Matanuska-Susitna Borough | 182 | 2022-05-02 |
| ABM/GCA Education Services | FL | DELTONA, FL, 32725 | 166 | 2022-05-05 |
| Colony Palm Beach | FL | PALM BEACH, FL, 33480 | 135 | 2022-05-31 |
| NDSM De Pere | WI | De Pere | 135 | 2022-05-10 |
| Sweda | CA | Los Angeles County | 130 | 2022-05-31 |
| Whole Foods Market | IL | Chicago, 959 W Fullerton Ave | 128 | 2022-05-02 |