| Company | State | Location | Workers | Notice date |
| Smithfield Distribution | CA | Los Angeles County | 1,755 | 2022-11-16 |
| Royal Farms Arena/ASM Global | MD | 201 W. Baltimore Street Baltimore, MD 21202 | 1,492 | 2022-02-02 |
| Universal Protection Service | WA | Seattle, Kent | 1,203 | 2022-10-21 |
| Walmart Fulfillment Center | IN | Plainfield | 1,132 | 2022-04-22 |
| United Furniture Amory (Monroe) | MS | — | 1,000 | 2022-11-21 |
| Aramark at University of Florida | FL | GAINESVILLE, FL, 32611 | 949 | 2022-04-18 |
| DynCorp International | MD | 47123 Buse Rd. #540 Patuxent River, MD 20670 | 937 | 2022-07-01 |
| Dreyer's Grand Ice Cream | CA | Kern County | 905 | 2022-09-27 |
| Twitter | CA | San Francisco County | 784 | 2022-11-07 |
| Invitae | CA | San Francisco County | 736 | 2022-07-27 |
| Miller's Health Systems | IN | Indianapolis, Wakarusa, Tipton, Sullivan, Rushville, Peru, LaGrange, and Huntington | 691 | 2022-05-02 |
| Watsonville Community Hospital (Update) | CO | Rural Consortium (Salida) | 673 | 2022-07-11 |
| Watsonville Community Hospital | CA | Santa Cruz County | 658 | 2022-03-23 |
| Watsonville Community Hospital (Update) | CO | Rural Consortium (Salida) | 658 | 2022-05-11 |
| Maryland Sportservice | MD | 333 W. Camden Street Baltimore, MD 21201 | 649 | 2022-09-30 |
| Cepheid | CA | Alameda County | 632 | 2022-10-31 |
| Meta Platforms | CA | San Mateo County | 632 | 2022-12-02 |
| Grocery Delivery E-Services | CA | Contra Costa County | 611 | 2022-10-11 |
| Greenwood Leflore Hospital Greenwood, (Leflore) | MS | — | 600 | 2022-10-05 |
| Ritz Carlton, Naples | FL | NAPLES, FL, 34108 | 591 | 2022-10-20 |