| Company | State | Location | Workers | Notice date |
| United Airlines | NJ | Newark | 3,899 | 2021-01-01 |
| United Airlines - SFO | CA | San Francisco, San Francisco County | 3,139 | 2021-02-23 |
| American Airlines-DFW | TX | DFW Airport, Tarrant | 2,475 | 2021-02-21 |
| YMCA of San Diego | CA | San Diego, San Diego County | 2,047 | 2021-03-04 |
| QVC Rocky Mount, Inc- Distribution Center | NC | Nash County | 1,953 | 2021-12-29 |
| Bicycle Casino | CA | Bell Gardens, Los Angeles County | 1,500 | 2021-01-04 |
| Mercy Hospital and Medical Center | IL | Chicago, 2525 S Michigan Ave | 1,400 | 2021-03-04 |
| YMCA of Greater Seattle | WA | Seattle | 1,213 | 2021-04-06 |
| American Airlines | MO | St. Louis (city) | 1,173 | 2021-02-08 |
| XPO Logistics | PA | Palmer, Northampton | 1,072 | 2021-03-01 |
| American Airlines | FL | MIAMI, FL, 33142 | 1,068 | 2021-02-09 |
| American Airlines | PA | Philadelphia, Philadelphia | 1,060 | 2021-02-01 |
| Prospect Airport Services | IL | Chicago, 10000 W O'Hare Ave Chicago 60666 5700 S. Cicero Ave. | 1,045 | 2021-05-25 |
| ABM Industry Groups | FL | JACKSONVILLE, FL, 32206 | 960 | 2021-04-27 |
| Hooters (Cook, DuPage, Lake, & Kendall Counties) | IL | Chicago, 660 North Wells Street | 951 | 2021-05-06 |
| United Airlines | NJ | Newark | 796 | 2021-07-01 |
| Cohn Restaurant Group | CA | San Diego, San Diego County | 758 | 2021-01-22 |
| People's United Bank/M&T Bank | CT | Hartford, Bridgeport, Farmington, Enfield, East Windsor, Cos Cob, North Haven, New Haven, South Windsor, Southington, Stamford, Wethersfield, Woodbridge | 747 | 2021-07-22 |
| Watsonville Community Hospital | CA | Santa Cruz County | 677 | 2021-11-30 |
| Mednax Services | FL | SUNRISE, FL, 33323 | 671 | 2021-08-04 |
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